[HTML][HTML] Krüppel-like factor 4 (KLF4/GKLF) is a target of bone morphogenetic proteins and transforming growth factor β1 in the regulation of vascular smooth muscle …
KE King, VP Iyemere, PL Weissberg… - Journal of Biological …, 2003 - ASBMB
Vascular smooth muscle cell (VSMC) differentiation and phenotypic modulation is
characterized by changes in mRNA expression for smooth muscle (SM) marker contractile
proteins such as α-SM actin and SM22α. Transforming growth factor β1 (TGF-β1) is a potent
VSMC differentiation factor; however, it is not known if other TGF-β-superfamily members, in
particular the bone morphogenetic proteins (BMPs), modulate VSMC phenotype. Here we
demonstrate that a large subset of TGF-β-superfamily members and their type I receptors are …
characterized by changes in mRNA expression for smooth muscle (SM) marker contractile
proteins such as α-SM actin and SM22α. Transforming growth factor β1 (TGF-β1) is a potent
VSMC differentiation factor; however, it is not known if other TGF-β-superfamily members, in
particular the bone morphogenetic proteins (BMPs), modulate VSMC phenotype. Here we
demonstrate that a large subset of TGF-β-superfamily members and their type I receptors are …