[HTML][HTML] Expression profiling of 519 kinase genes in matched malignant peripheral nerve sheath tumor/plexiform neurofibroma samples is discriminatory and identifies …
TP Stricker, KJ Henriksen, JH Tonsgard, AG Montag… - Modern Pathology, 2013 - Elsevier
About 50% of all malignant peripheral nerve sheath tumors (MPNSTs) arise as
neurofibromatosis type 1 associated lesions. In those patients malignant peripheral nerve
sheath tumors are thought to arise through malignant transformation of a preexisting
plexiform neurofibroma. The molecular changes associated with this transformation are still
poorly understood. We sought to test the hypothesis that dysregulation of expression of
kinases contributes to this malignant transformation. We analyzed expression of all 519 …
neurofibromatosis type 1 associated lesions. In those patients malignant peripheral nerve
sheath tumors are thought to arise through malignant transformation of a preexisting
plexiform neurofibroma. The molecular changes associated with this transformation are still
poorly understood. We sought to test the hypothesis that dysregulation of expression of
kinases contributes to this malignant transformation. We analyzed expression of all 519 …