Effects of estradiol on the metabolism of arachidonic acid by aortas and platelets in rats

C Wen-Chang, N Junko, N Tomohiro, O Hajime… - … et Biophysica Acta (BBA …, 1981 - Elsevier
We have previously reported that estradiol treatment stimulates prostacyclin production by
cultured rat aortic smooth muscle cells, through the stimulation of fatty acid cyclooxygenase
and prostacyclin synthetase activities. In order to see whether estradiol stimulates the fatty
acid cyclooxygenase activity in platelets, intact rats were treated with estradiol, and
thromboxane biosynthesis in platelets and prostacyclin production by aortas were
investigated. Estradiol significantly stimulates prostacyclin production by aortas. However …