Infralimbic D2 receptors are necessary for fear extinction and extinction-related tone responses
D Mueller, C Bravo-Rivera, GJ Quirk - Biological psychiatry, 2010 - Elsevier
BACKGROUND:: Fear extinction is dependent on plasticity in the infralimbic prefrontal
cortex, an area heavily innervated by midbrain dopaminergic inputs. Dopamine D2
receptors are concentrated in infralimbic output neurons that are involved in the suppression
of conditioned fear after extinction. Here, we examined the specific role of infralimbic D2
receptors in mediating associative learning underlying fear extinction using the selective D2
antagonist raclopride. METHODS:: Raclopride was administered systemically or infused into …
cortex, an area heavily innervated by midbrain dopaminergic inputs. Dopamine D2
receptors are concentrated in infralimbic output neurons that are involved in the suppression
of conditioned fear after extinction. Here, we examined the specific role of infralimbic D2
receptors in mediating associative learning underlying fear extinction using the selective D2
antagonist raclopride. METHODS:: Raclopride was administered systemically or infused into …