Background Cerebral cavernous malformations (CCMs) are reported to exhibit a wide range
of dynamic patterns including growth, regression, and de novo formation, which generally
show slow and steady courses. Although the pathogenesis of CCMs is not well known,
vascular endothelial growth factor (VEGF) has been suggested as a possible mediating
factor. Objectives To report CCMs showing rapid progression over a short period and to
investigate these biological characteristics. Design Experimental study. Setting Tertiary …