Reactive astrogliosis has long been recognized as a ubiquitous feature of CNS pathologies.
Although its roles in CNS pathology are only beginning to be defined, genetic tools are
enabling molecular dissection of the functions and mechanisms of reactive astrogliosis in
vivo. It is now clear that reactive astrogliosis is not simply an all-or-nothing phenomenon but,
rather, is a finely gradated continuum of molecular, cellular, and functional changes that
range from subtle alterations in gene expression to scar formation. These changes can exert …