PDCD10, the gene mutated in cerebral cavernous malformation 3, is expressed in the neurovascular unit
G Tanriover, AJ Boylan, ML DiLuna, KL Pricola… - …, 2008 - journals.lww.com
OBJECTIVE: Mutations in the programmed cell death 10 gene, PDCD10, cause the
autosomal-dominant familial cerebral cavernous malformation 3 (CCM3). Little is known
about the function of this gene in disease pathogenesis. METHODS: As a first step, we
analyzed the messenger ribonucleic acid (mRNA) expression of CCM3 in the embryonic
and postnatal mouse brain by in situ hybridization. We generated and characterized CCM3-
specific polyclonal antibodies and analyzed CCM3 protein expression in human cerebral …
autosomal-dominant familial cerebral cavernous malformation 3 (CCM3). Little is known
about the function of this gene in disease pathogenesis. METHODS: As a first step, we
analyzed the messenger ribonucleic acid (mRNA) expression of CCM3 in the embryonic
and postnatal mouse brain by in situ hybridization. We generated and characterized CCM3-
specific polyclonal antibodies and analyzed CCM3 protein expression in human cerebral …