The factors governing neuronal loss in Parkinson's disease (PD) are the subject of
continuing speculation and experimental study. In recent years, factors that act on most or all
cell types (pan-cellular factors), particularly genetic mutations and environmental toxins,
have dominated public discussions of disease aetiology. Although there is compelling
evidence supporting an association between disease risk and these factors, the pattern of
neuronal pathology and cell loss is difficult to explain without cell-specific factors. This …