Neuroprotective effects of short-chain fatty acids in MPTP induced mice model of Parkinson's disease
Y Hou, X Li, C Liu, M Zhang, X Zhang, S Ge… - Experimental …, 2021 - Elsevier
Gut microbial metabolites, SCFAs, were related with the occurrence and development of
Parkinson's disease (PD). But the effects of different short-chain fatty acids (SCFAs) on PD
and involving mechanisms are still undefined. In this study we evaluate the effects of three
dominant SCFAs (acetate, propionate and butyrate) on motor damage, dopaminergic
neuronal degeneration and underlying neuroinflammation related mechanisms in 1-methyl-
4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced PD mice. High (2.0 g/kg) or low doses …
Parkinson's disease (PD). But the effects of different short-chain fatty acids (SCFAs) on PD
and involving mechanisms are still undefined. In this study we evaluate the effects of three
dominant SCFAs (acetate, propionate and butyrate) on motor damage, dopaminergic
neuronal degeneration and underlying neuroinflammation related mechanisms in 1-methyl-
4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced PD mice. High (2.0 g/kg) or low doses …