Immunosenescence is defined as the progressive deterioration of the immune system with
aging. Immunosenescence stifles the generation of protective B and T cell-mediated
adaptive immunity in response to various pathogens, resulting in increased disease
susceptibility and severity in the elderly population. In particular, immunosenescence has
major impacts on the phenotype, function, and receptor repertoire of B and T cells in the
elderly, hindering protective responses induced by seasonal influenza virus vaccination. In …