Plasmablast antibody repertoires in elderly influenza vaccine responders exhibit restricted diversity but increased breadth of binding across influenza strains
CH Ju, LK Blum, S Kongpachith, N Lingampalli… - Clinical …, 2018 - Elsevier
Seasonal influenza vaccines elicit antibody responses that can prevent infection, but their
efficacy is reduced in the elderly. While a subset of elderly individuals can still mount
sufficient vaccine-induced antibody responses, little is known about the properties of the
vaccine-induced antibody repertoires in elderly as compared to young responders. To gain
insights into the effects of aging on influenza vaccine-induced antibody responses, we used
flow cytometry and a cell-barcoding method to sequence antibody heavy and light chain …
efficacy is reduced in the elderly. While a subset of elderly individuals can still mount
sufficient vaccine-induced antibody responses, little is known about the properties of the
vaccine-induced antibody repertoires in elderly as compared to young responders. To gain
insights into the effects of aging on influenza vaccine-induced antibody responses, we used
flow cytometry and a cell-barcoding method to sequence antibody heavy and light chain …