2. Materials and methods In order to quantitatively assess the link between vaccine
immunogenicity and efficacy, a computerised literature search was undertaken using
MEDLINE (National Library of Medicine, Bethesda MD, USA) and Excerpta Medica (Elsevier
Science BV, Amsterdam, Netherlands) databases. Key words used in the search were
antibody, protection, influenza, immunogenicity and efficacy. Abstracts of each retrieved
article were reviewed and papers were selected for inclusion according to their relevance …