[HTML][HTML] Sirtuin 5 is required for mouse survival in response to cardiac pressure overload
KA Hershberger, DM Abraham, AS Martin… - Journal of Biological …, 2017 - ASBMB
In mitochondria, the sirtuin SIRT5 is an NAD+-dependent protein deacylase that controls
several metabolic pathways. Although a wide range of SIRT5 targets have been identified,
the overall function of SIRT5 in organismal metabolic homeostasis remains unclear. Given
that SIRT5 expression is highest in the heart and that sirtuins are commonly stress-response
proteins, we used an established model of pressure overload–induced heart muscle
hypertrophy caused by transverse aortic constriction (TAC) to determine SIRT5's role in …
several metabolic pathways. Although a wide range of SIRT5 targets have been identified,
the overall function of SIRT5 in organismal metabolic homeostasis remains unclear. Given
that SIRT5 expression is highest in the heart and that sirtuins are commonly stress-response
proteins, we used an established model of pressure overload–induced heart muscle
hypertrophy caused by transverse aortic constriction (TAC) to determine SIRT5's role in …