T cell metabolism drives immunity

MD Buck, D O'sullivan, EL Pearce - Journal of Experimental Medicine, 2015 - rupress.org
MD Buck, D O'sullivan, EL Pearce
Journal of Experimental Medicine, 2015rupress.org
Lymphocytes must adapt to a wide array of environmental stressors as part of their normal
development, during which they undergo a dramatic metabolic remodeling process.
Research in this area has yielded surprising findings on the roles of diverse metabolic
pathways and metabolites, which have been found to regulate lymphocyte signaling and
influence differentiation, function and fate. In this review, we integrate the latest findings in
the field to provide an up-to-date resource on lymphocyte metabolism.
Lymphocytes must adapt to a wide array of environmental stressors as part of their normal development, during which they undergo a dramatic metabolic remodeling process. Research in this area has yielded surprising findings on the roles of diverse metabolic pathways and metabolites, which have been found to regulate lymphocyte signaling and influence differentiation, function and fate. In this review, we integrate the latest findings in the field to provide an up-to-date resource on lymphocyte metabolism.
rupress.org