Fatty acids are a major energy source and important constituents of membrane lipids, and
they serve as cellular signaling molecules that play an important role in the etiology of the
metabolic syndrome. Acetyl-CoA carboxylases 1 and 2 (ACC1 and ACC2) catalyze the
synthesis of malonyl-CoA, the substrate for fatty acid synthesis and the regulator of fatty acid
oxidation. They are highly regulated and play important roles in the energy metabolism of
fatty acids in animals, including humans. They are presently considered as an attractive …