Chronic inflammation after severe traumatic brain injury: characterization and associations with outcome at 6 and 12 months postinjury
Objective: Examine associations between chronic inflammatory profiles and outcome 6 to 12
months following severe traumatic brain injury (TBI). Setting: University-affiliated level 1
trauma center and community. Participants: Adults with severe TBI (n= 87); healthy controls
(n= 7). Design: Prospective cohort study. Main Measures: Glasgow Outcome Scale; serum
cytokines (interleukin [IL]-1β, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12, tumor necrosis factor α),
2 weeks to 3 months, 4-to 6-month averages, 6-and 12-month levels. Results: Serum levels …
months following severe traumatic brain injury (TBI). Setting: University-affiliated level 1
trauma center and community. Participants: Adults with severe TBI (n= 87); healthy controls
(n= 7). Design: Prospective cohort study. Main Measures: Glasgow Outcome Scale; serum
cytokines (interleukin [IL]-1β, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12, tumor necrosis factor α),
2 weeks to 3 months, 4-to 6-month averages, 6-and 12-month levels. Results: Serum levels …