Short-chain fatty acids (SCFAs) alone or in combination regulate select immune functions of microglia-like cells
TJ Wenzel, EJ Gates, AL Ranger, A Klegeris - Molecular and Cellular …, 2020 - Elsevier
Neuroinflammation contributes to neurodegenerative disorders, including Alzheimer's
disease (AD). Gut microbes are involved in regulating systemic inflammation. Short-chain
fatty acids (SCFAs), which are among the many metabolites released by gut microbes, can
cross the blood-brain barrier (BBB) and interact with microglia. High concentrations of
individual SCFAs decrease the inflammatory responses of peripheral monocytes; therefore,
we hypothesized that SCFAs act on their own or in combinations to reduce the inflammatory …
disease (AD). Gut microbes are involved in regulating systemic inflammation. Short-chain
fatty acids (SCFAs), which are among the many metabolites released by gut microbes, can
cross the blood-brain barrier (BBB) and interact with microglia. High concentrations of
individual SCFAs decrease the inflammatory responses of peripheral monocytes; therefore,
we hypothesized that SCFAs act on their own or in combinations to reduce the inflammatory …