Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infection
DJ Colby, L Trautmann, S Pinyakorn, L Leyre… - Nature medicine, 2018 - nature.com
Nature medicine, 2018•nature.com
Antiretroviral therapy during the earliest stage of acute HIV infection (Fiebig I) might
minimize establishment of a latent HIV reservoir and thereby facilitate viremic control after
analytical treatment interruption. We show that 8 participants, who initiated treatment during
Fiebig I and were treated for a median of 2.8 years, all experienced rapid viral load rebound
following analytical treatment interruption, indicating that additional strategies are required
to control or eradicate HIV.
minimize establishment of a latent HIV reservoir and thereby facilitate viremic control after
analytical treatment interruption. We show that 8 participants, who initiated treatment during
Fiebig I and were treated for a median of 2.8 years, all experienced rapid viral load rebound
following analytical treatment interruption, indicating that additional strategies are required
to control or eradicate HIV.
Abstract
Antiretroviral therapy during the earliest stage of acute HIV infection (Fiebig I) might minimize establishment of a latent HIV reservoir and thereby facilitate viremic control after analytical treatment interruption. We show that 8 participants, who initiated treatment during Fiebig I and were treated for a median of 2.8 years, all experienced rapid viral load rebound following analytical treatment interruption, indicating that additional strategies are required to control or eradicate HIV.
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