[HTML][HTML] Predominance of weakly cytotoxic, T-betLowEomesNeg CD8+ T-cells in human gastrointestinal mucosa: implications for HIV infection
BE Kiniry, A Ganesh, JW Critchfield, PW Hunt… - Mucosal …, 2017 - Elsevier
The gastrointestinal mucosa is an important site of HIV acquisition, viral replication, and
pathogenesis. Immune cells in mucosal tissues frequently differ in phenotype and function
from their non-mucosal counterparts. Although perforin-mediated cytotoxicity as measured in
blood is a recognized correlate of HIV immune control, its role in gastrointestinal tissues is
unknown. We sought to elucidate the cytotoxic features of rectal mucosal CD8+ T-cells in
HIV infected and uninfected subjects. Perforin expression and lytic capacity were …
pathogenesis. Immune cells in mucosal tissues frequently differ in phenotype and function
from their non-mucosal counterparts. Although perforin-mediated cytotoxicity as measured in
blood is a recognized correlate of HIV immune control, its role in gastrointestinal tissues is
unknown. We sought to elucidate the cytotoxic features of rectal mucosal CD8+ T-cells in
HIV infected and uninfected subjects. Perforin expression and lytic capacity were …