[HTML][HTML] miR-132 enhances HIV-1 replication
K Chiang, H Liu, AP Rice - Virology, 2013 - Elsevier
K Chiang, H Liu, AP Rice
Virology, 2013•ElsevierMicroRNAs upregulated during CD4+ T cell activation may contribute to the increased
efficiency of HIV-1 replication seen following perturbation of the resting state. We have found
miR-132 to be highly upregulated following CD4+ T cell activation, and show that miR-132
potentiates viral replication in the Jurkat CD4+ T cell line. Knockdown of MeCP2, a
previously identified target of miR-132, also increases HIV-1 replication. To the best of our
knowledge, miR-132 is the first miRNA reported to enhance HIV-1 replication.
efficiency of HIV-1 replication seen following perturbation of the resting state. We have found
miR-132 to be highly upregulated following CD4+ T cell activation, and show that miR-132
potentiates viral replication in the Jurkat CD4+ T cell line. Knockdown of MeCP2, a
previously identified target of miR-132, also increases HIV-1 replication. To the best of our
knowledge, miR-132 is the first miRNA reported to enhance HIV-1 replication.
Abstract
MicroRNAs upregulated during CD4+ T cell activation may contribute to the increased efficiency of HIV-1 replication seen following perturbation of the resting state. We have found miR-132 to be highly upregulated following CD4+ T cell activation, and show that miR-132 potentiates viral replication in the Jurkat CD4+ T cell line. Knockdown of MeCP2, a previously identified target of miR-132, also increases HIV-1 replication. To the best of our knowledge, miR-132 is the first miRNA reported to enhance HIV-1 replication.
Elsevier