[HTML][HTML] MicroRNA profile changes in human immunodeficiency virus type 1 (HIV-1) seropositive individuals
L Houzet, ML Yeung, V de Lame, D Desai, SM Smith… - Retrovirology, 2008 - Springer
L Houzet, ML Yeung, V de Lame, D Desai, SM Smith, KT Jeang
Retrovirology, 2008•SpringerMicroRNAs (miRNAs) play diverse roles in regulating cellular and developmental functions.
We have profiled the miRNA expression in peripheral blood mononuclear cells from 36 HIV-
1 seropositive individuals and 12 normal controls. The HIV-1-positive individuals were
categorized operationally into four classes based on their CD4+ T-cell counts and their viral
loads. We report that specific miRNA signatures can be observed for each of the four
classes.
We have profiled the miRNA expression in peripheral blood mononuclear cells from 36 HIV-
1 seropositive individuals and 12 normal controls. The HIV-1-positive individuals were
categorized operationally into four classes based on their CD4+ T-cell counts and their viral
loads. We report that specific miRNA signatures can be observed for each of the four
classes.
Abstract
MicroRNAs (miRNAs) play diverse roles in regulating cellular and developmental functions. We have profiled the miRNA expression in peripheral blood mononuclear cells from 36 HIV-1 seropositive individuals and 12 normal controls. The HIV-1-positive individuals were categorized operationally into four classes based on their CD4+ T-cell counts and their viral loads. We report that specific miRNA signatures can be observed for each of the four classes.
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