Fibrosis with inflammation at one year predicts transplant functional decline
WD Park, MD Griffin, LD Cornell, FG Cosio… - Journal of the …, 2010 - journals.lww.com
Lack of knowledge regarding specific causes for late loss of kidney transplants hampers
improvements in long-term allograft survival. Kidney transplants with both interstitial fibrosis
and subclinical inflammation but not fibrosis alone after 1 year have reduced survival. This
study tested whether fibrosis with inflammation at 1 year associates with decline of renal
function in a low-risk cohort and characterized the nature of the inflammation. We studied
151 living-donor, tacrolimus/mycophenolate-treated recipients without overt risk factors for …
improvements in long-term allograft survival. Kidney transplants with both interstitial fibrosis
and subclinical inflammation but not fibrosis alone after 1 year have reduced survival. This
study tested whether fibrosis with inflammation at 1 year associates with decline of renal
function in a low-risk cohort and characterized the nature of the inflammation. We studied
151 living-donor, tacrolimus/mycophenolate-treated recipients without overt risk factors for …