Breast regression protein–39/chitinase 3–like 1 promotes renal fibrosis after kidney injury via activation of myofibroblasts
TA Montgomery, L Xu, S Mason… - Journal of the …, 2017 - journals.lww.com
The normal response to kidney injury includes a robust inflammatory infiltrate of PMNs and
macrophages. We previously showed that the small secreted protein breast regression
protein–39 (BRP-39), also known as chitinase 3–like 1 (CHI3L1) and encoded by the Chi3l1
gene, is expressed at high levels by macrophages during the early stages of kidney repair
and promotes tubular cell survival via IL-13 receptor α2 (IL13Rα2)–mediated signaling.
Here, we investigated the role of BRP-39 in profibrotic responses after AKI. In wild-type mice …
macrophages. We previously showed that the small secreted protein breast regression
protein–39 (BRP-39), also known as chitinase 3–like 1 (CHI3L1) and encoded by the Chi3l1
gene, is expressed at high levels by macrophages during the early stages of kidney repair
and promotes tubular cell survival via IL-13 receptor α2 (IL13Rα2)–mediated signaling.
Here, we investigated the role of BRP-39 in profibrotic responses after AKI. In wild-type mice …