[HTML][HTML] The anti-apoptotic effect of Notch-1 requires p56lck-dependent, Akt/PKB-mediated signaling in T cells

H Sade, S Krishna, A Sarin - Journal of Biological Chemistry, 2004 - ASBMB
The Notch family of transmembrane receptors have been implicated in a variety of cellular
decisions in different cell types. Here we investigate the mechanism underlying Notch-1-
mediated anti-apoptotic function in T cells using model cell lines as the experimental system.
Ectopic expression of the intracellular domain of Notch-1/activated Notch (AcN1) increases
expression of anti-apoptotic proteins of the inhibitors of apoptosis (IAP) family, the Bcl-2
family, and the FLICE-like inhibitor protein (FLIP) and inhibits death triggered by multiple …