[HTML][HTML] Phosphorylation of the LFA-1 integrin β2-chain on Thr-758 leads to adhesion, Rac-1/Cdc42 activation, and stimulation of CD69 expression in human T cells
SM Nurmi, M Autero, AK Raunio, CG Gahmberg… - Journal of biological …, 2007 - ASBMB
Phosphorylation of the leukocyte function-associated antigen-1 (LFA-1) integrin β2-chain on
Thr-758 occurs after T cell receptor stimulation and leads to 14-3-3 recruitment to the
integrin, actin cytoskeleton reorganization, and increased adhesion. Here, we have
investigated the signaling effects of β2 integrin Thr-758 phosphorylation. A penetratin-
coupled phospho-Thr-758-β2 peptide (mimicking the part of the integrin β-chain surrounding
Thr-758) stimulated adhesion of human T cells to the LFA-1 ligand intercellular adhesion …
Thr-758 occurs after T cell receptor stimulation and leads to 14-3-3 recruitment to the
integrin, actin cytoskeleton reorganization, and increased adhesion. Here, we have
investigated the signaling effects of β2 integrin Thr-758 phosphorylation. A penetratin-
coupled phospho-Thr-758-β2 peptide (mimicking the part of the integrin β-chain surrounding
Thr-758) stimulated adhesion of human T cells to the LFA-1 ligand intercellular adhesion …