[HTML][HTML] Cobalt inhibits the interaction between hypoxia-inducible factor-α and von Hippel-Lindau protein by direct binding to hypoxia-inducible factor-α
Y Yuan, G Hilliard, T Ferguson, DE Millhorn - Journal of Biological …, 2003 - ASBMB
The hypoxia-inducible factor (HIF) activates the expression of genes that contain a hypoxia
response element. The α-subunits of the HIF transcription factors are degraded by
proteasomal pathways during normoxia but are stabilized under hypoxic conditions. The von
Hippel-Lindau protein (pVHL) mediates the ubiquitination and rapid degradation of HIF-α
(including HIF-1α and HIF-2α). Post-translational hydroxylation of a proline residue in the
oxygen-dependent degradation (ODD) domain of HIF-α is required for the interaction …
response element. The α-subunits of the HIF transcription factors are degraded by
proteasomal pathways during normoxia but are stabilized under hypoxic conditions. The von
Hippel-Lindau protein (pVHL) mediates the ubiquitination and rapid degradation of HIF-α
(including HIF-1α and HIF-2α). Post-translational hydroxylation of a proline residue in the
oxygen-dependent degradation (ODD) domain of HIF-α is required for the interaction …