Idiopathic pulmonary fibrosis (IPF) is one of many clinical syndromes that are associated
with aging, and is increasing in both incidence and prevalence with the rapid rise in aging
populations world-wide. There is accumulating data on how the biology of aging may
influence the susceptibility to lung fibrosis in the elderly. In this review, we explore some of
the known “hallmarks of aging,” including telomere attrition, genomic instability, epigenetic
alterations, loss of proteostasis, cellular senescence and mitochondrial dysfunction in the …