[HTML][HTML] The myeloid-specific sialic acid-binding receptor, CD33, associates with the protein-tyrosine phosphatases, SHP-1 and SHP-2
The myeloid restricted membrane glycoprotein, CD33, is a member of the recently
characterized" sialic acid-binding immunoglobulin-related lectin" family. Although CD33 can
mediate sialic acid-dependent cell interactions as a recombinant protein, its function in
myeloid cells has yet to be determined. Since CD33 contains two potential immunoreceptor
tyrosine-based inhibition motifs in its cytoplasmic tail, we investigated whether it might act as
a signaling receptor in myeloid cells. Tyrosine phosphorylation of CD33 in myeloid cell lines …
characterized" sialic acid-binding immunoglobulin-related lectin" family. Although CD33 can
mediate sialic acid-dependent cell interactions as a recombinant protein, its function in
myeloid cells has yet to be determined. Since CD33 contains two potential immunoreceptor
tyrosine-based inhibition motifs in its cytoplasmic tail, we investigated whether it might act as
a signaling receptor in myeloid cells. Tyrosine phosphorylation of CD33 in myeloid cell lines …