Airway exposure initiates peanut allergy by involving the IL-1 pathway and T follicular helper cells in mice

JJ Dolence, T Kobayashi, K Iijima, J Krempski… - Journal of Allergy and …, 2018 - Elsevier
Background Little is currently known regarding the immunologic mechanism (s) that initiate
peanut allergy. Notably, peanut proteins have been detected in house dust, and their levels
correlate with peanut allergy prevalence. Objective This study aimed to develop a new
mouse model for peanut allergy and to investigate the immunologic mechanisms involved in
peanut allergen sensitization. Methods To mimic environmental exposure, naive mice were
exposed to peanut flour by inhalation for up to 4 weeks. We then analyzed serum levels of …