The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells
AT Bauquet, H Jin, AM Paterson, M Mitsdoerffer… - Nature …, 2009 - nature.com
AT Bauquet, H Jin, AM Paterson, M Mitsdoerffer, IC Ho, AH Sharpe, VK Kuchroo
Nature immunology, 2009•nature.comThe inducible costimulatory molecule ICOS has been suggested to be important in the
development of interleukin 17 (IL-17)-producing helper T cells (TH-17 cells) and of follicular
helper T cells (TFH cells). Here we show that ICOS-deficient mice had no defect in TH-17
differentiation but had fewer TH-17 cells after IL-23 stimulation and fewer TFH cells. We also
show that TFH cells produced IL-17 and that TFH cells in ICOS-deficient mice were defective
in IL-17 production. Both TH-17 and TFH cells had higher expression of the transcription …
development of interleukin 17 (IL-17)-producing helper T cells (TH-17 cells) and of follicular
helper T cells (TFH cells). Here we show that ICOS-deficient mice had no defect in TH-17
differentiation but had fewer TH-17 cells after IL-23 stimulation and fewer TFH cells. We also
show that TFH cells produced IL-17 and that TFH cells in ICOS-deficient mice were defective
in IL-17 production. Both TH-17 and TFH cells had higher expression of the transcription …
Abstract
The inducible costimulatory molecule ICOS has been suggested to be important in the development of interleukin 17 (IL-17)-producing helper T cells (TH-17 cells) and of follicular helper T cells (TFH cells). Here we show that ICOS-deficient mice had no defect in TH-17 differentiation but had fewer TH-17 cells after IL-23 stimulation and fewer TFH cells. We also show that TFH cells produced IL-17 and that TFH cells in ICOS-deficient mice were defective in IL-17 production. Both TH-17 and TFH cells had higher expression of the transcription factor c-Maf. Genetic loss of c-Maf resulted in a defect in IL-21 production and fewer TH-17 and TFH cells. Thus our data suggest that ICOS-induced c-Maf regulates IL-21 production that in turn regulates the expansion of TH-17 and TFH cells.
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