[HTML][HTML] V617F JAK-2 mutation in patients with essential thrombocythemia: relation to platelet, granulocyte, and plasma hemostatic and inflammatory molecules
A Falanga, M Marchetti, A Vignoli, D Balducci… - Experimental …, 2007 - Elsevier
OBJECTIVE: This article evaluates patients with essential thrombocythemia (ET) to
determine whether the V617F mutation in the JAK2 gene affects platelet hemostatic and
adhesive molecules, platelet-polymorphonuclear leukocyte (PMN) interactions, and PMN-
activation characteristics, as well as plasma hypercoagulation markers. PATIENTS AND
METHODS: Thirty-seven ET patients with V617F JAK2 mutation and 38 wild-type, and 50
healthy controls were studied. RESULTS: Platelets from overall ET patients, compared to …
determine whether the V617F mutation in the JAK2 gene affects platelet hemostatic and
adhesive molecules, platelet-polymorphonuclear leukocyte (PMN) interactions, and PMN-
activation characteristics, as well as plasma hypercoagulation markers. PATIENTS AND
METHODS: Thirty-seven ET patients with V617F JAK2 mutation and 38 wild-type, and 50
healthy controls were studied. RESULTS: Platelets from overall ET patients, compared to …