[HTML][HTML] Involvement of poly (ADP-ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining
M Audebert, B Salles, P Calsou - Journal of Biological Chemistry, 2004 - ASBMB
The efficient repair of DNA double-strand breaks (DSBs) is critical for the maintenance of
genomic integrity. In mammalian cells, the nonhomologous end-joining process that
represents the predominant repair pathway relies on the DNA-dependent protein kinase
(DNA-PK) and the XRCC4-DNA ligase IV complex. Nonetheless, several in vitro and in vivo
results indicate that mammalian cells use more than a single end-joining mechanism. While
searching for a DNA-PK-independent end-joining activity, we found that the pretreatment of …
genomic integrity. In mammalian cells, the nonhomologous end-joining process that
represents the predominant repair pathway relies on the DNA-dependent protein kinase
(DNA-PK) and the XRCC4-DNA ligase IV complex. Nonetheless, several in vitro and in vivo
results indicate that mammalian cells use more than a single end-joining mechanism. While
searching for a DNA-PK-independent end-joining activity, we found that the pretreatment of …