[HTML][HTML] GPIHBP1, an endothelial cell transporter for lipoprotein lipase
SG Young, BSJ Davies, CV Voss, P Gin… - Journal of lipid …, 2011 - ASBMB
Interest in lipolysis and the metabolism of triglyceride-rich lipoproteins was recently reignited
by the discovery of severe hypertriglyceridemia (chylomicronemia) in
glycosylphosphatidylinositol-anchored high density lipoprotein–binding protein 1
(GPIHBP1)-deficient mice. GPIHBP1 is expressed exclusively in capillary endothelial cells
and binds lipoprotein lipase (LPL) avidly. These findings prompted speculation that
GPIHBP1 serves as a binding site for LPL in the capillary lumen, creating" a platform for …
by the discovery of severe hypertriglyceridemia (chylomicronemia) in
glycosylphosphatidylinositol-anchored high density lipoprotein–binding protein 1
(GPIHBP1)-deficient mice. GPIHBP1 is expressed exclusively in capillary endothelial cells
and binds lipoprotein lipase (LPL) avidly. These findings prompted speculation that
GPIHBP1 serves as a binding site for LPL in the capillary lumen, creating" a platform for …