Apolipoprotein B: structure, biosynthesis and role in the lipoprotein assembly process
SO Olofsson, G Bjursell, K Boström, P Carlsson… - Atherosclerosis, 1987 - Elsevier
The complete amino acid sequence of the liver-synthesized apolipoprotein B (apoB)
species, apoB 100, has been derived from cloned cDNA. The protein consists of 4536 amino
acids (+ a 27 amino acid signal sequence). Cysteine is clustered in the N-terminal 1 10 of
the protein, suggesting the presence of a stabilized tertiary structure in this part of the
molecule. Three types of structure are suggested to be of importance for the binding of the
protein to lipids;(i) hydrophobic sequences with a high probability for beta-sheet structure,(ii) …
species, apoB 100, has been derived from cloned cDNA. The protein consists of 4536 amino
acids (+ a 27 amino acid signal sequence). Cysteine is clustered in the N-terminal 1 10 of
the protein, suggesting the presence of a stabilized tertiary structure in this part of the
molecule. Three types of structure are suggested to be of importance for the binding of the
protein to lipids;(i) hydrophobic sequences with a high probability for beta-sheet structure,(ii) …