YAP/TAZ are mechanoregulators of TGF-β-Smad signaling and renal fibrogenesis
SG Szeto, M Narimatsu, M Lu, X He… - Journal of the …, 2016 - journals.lww.com
Like many organs, the kidney stiffens after injury, a process that is increasingly recognized
as an important driver of fibrogenesis. Yes-associated protein (YAP) and transcriptional
coactivator with PDZ-binding motif (TAZ) are related mechanosensory proteins that bind to
Smad transcription factors, the canonical mediators of profibrotic TGF-β responses. Here, we
investigated the role of YAP/TAZ in the matrix stiffness dependence of fibroblast responses
to TGF-β. In contrast to growth on a stiff surface, fibroblast growth on a soft matrix led to …
as an important driver of fibrogenesis. Yes-associated protein (YAP) and transcriptional
coactivator with PDZ-binding motif (TAZ) are related mechanosensory proteins that bind to
Smad transcription factors, the canonical mediators of profibrotic TGF-β responses. Here, we
investigated the role of YAP/TAZ in the matrix stiffness dependence of fibroblast responses
to TGF-β. In contrast to growth on a stiff surface, fibroblast growth on a soft matrix led to …