[HTML][HTML] Detection of HIV-1-specific gastrointestinal tissue resident CD8+ T-cells in chronic infection
Tissue-resident memory (T RM) CD8+ T-cells are non-recirculating, long-lived cells housed
in tissues that can confer protection against mucosal pathogens. Human immunodeficiency
virus-1 (HIV-1) is a mucosal pathogen and the gastrointestinal tract is an important site of
viral pathogenesis and transmission. Thus, CD8+ T RM cells may be an important effector
subset for controlling HIV-1 in mucosal tissues. This study sought to determine the
abundance, phenotype, and functionality of CD8+ T RM cells in the context of chronic HIV-1 …
in tissues that can confer protection against mucosal pathogens. Human immunodeficiency
virus-1 (HIV-1) is a mucosal pathogen and the gastrointestinal tract is an important site of
viral pathogenesis and transmission. Thus, CD8+ T RM cells may be an important effector
subset for controlling HIV-1 in mucosal tissues. This study sought to determine the
abundance, phenotype, and functionality of CD8+ T RM cells in the context of chronic HIV-1 …