TMPRSS2: A potential target for treatment of influenza virus and coronavirus infections

LW Shen, HJ Mao, YL Wu, Y Tanaka, W Zhang - Biochimie, 2017 - Elsevier
Influenza virus and coronavirus epidemics or pandemics have occurred in succession
worldwide throughout the early 21st century. These epidemics or pandemics pose a major
threat to human health. Here, we outline a critical role of the host cell protease TMPRSS2 in
influenza virus and coronavirus infections and highlight an antiviral therapeutic strategy
targeting TMPRSS2.