The large gene family encoding the regulators of G protein signaling (RGS) proteins has
been implicated in the fine tuning of a variety of cellular events in response to G protein-
coupled receptor activation. Several studies have shown that the RGS proteins can
attenuate G protein-activated extracellular signal-regulated kinase (ERK) group of mitogen-
activated protein kinases. We demonstrate herein that the production of inositol
trisphosphate and the activation of the p38 group of mitogen-activated protein kinases by the …