[HTML][HTML] Enteroendocrine cells-sensory sentinels of the intestinal environment and orchestrators of mucosal immunity
JJ Worthington, F Reimann, FM Gribble - Mucosal immunology, 2018 - Elsevier
The intestinal epithelium must balance efficient absorption of nutrients with partitioning
commensals and pathogens from the bodies' largest immune system. If this crucial barrier
fails, inappropriate immune responses can result in inflammatory bowel disease or chronic
infection. Enteroendocrine cells represent 1% of this epithelium and have classically been
studied for their detection of nutrients and release of peptide hormones to mediate digestion.
Intriguingly, enteroendocrine cells are the key sensors of microbial metabolites, can release …
commensals and pathogens from the bodies' largest immune system. If this crucial barrier
fails, inappropriate immune responses can result in inflammatory bowel disease or chronic
infection. Enteroendocrine cells represent 1% of this epithelium and have classically been
studied for their detection of nutrients and release of peptide hormones to mediate digestion.
Intriguingly, enteroendocrine cells are the key sensors of microbial metabolites, can release …