MicroRNAs (miRNAs) are integral molecules in the regulation of numerous physiological
cellular processes that have emerged as critical players in cancer initiation and metastatic
progression, both by promoting and suppressing metastasis. Recently, cell-free miRNAs
shed from cancer cells into circulation have been reported in cancer patients, raising hope
for development of novel biomarkers that can be routinely measured in easily accessible
samples. In fact, establishing miRNA expression in the circulation likely has advantages …

miRNAs are a class of small, non-coding RNAs that regulate cancer progression, especially
the processes of invasion and metastasis. Although earlier studies in metastasis primarily
focused on the impact that miRNAs have on the intrinsic properties of cancer cells, recent
reports reveal that miRNAs also shape interactions between cancer cells and their
associated stroma. In this review, we discuss current known mechanisms by which miRNAs
execute their microenvironmental regulation of cancer metastasis, including regulating …