Associations of luminal and basal subtyping of prostate cancer with prognosis and response to androgen deprivation therapy
Importance There is a clear need for a molecular subtyping approach in prostate cancer to
identify clinically distinct subgroups that benefit from specific therapies. Objectives To
identify prostate cancer subtypes based on luminal and basal lineage and to determine
associations with clinical outcomes and response to treatment. Design, Setting, and
Participants The PAM50 classifier was used to subtype 1567 retrospectively collected
(median follow-up, 10 years) and 2215 prospectively collected prostate cancer samples into …
identify clinically distinct subgroups that benefit from specific therapies. Objectives To
identify prostate cancer subtypes based on luminal and basal lineage and to determine
associations with clinical outcomes and response to treatment. Design, Setting, and
Participants The PAM50 classifier was used to subtype 1567 retrospectively collected
(median follow-up, 10 years) and 2215 prospectively collected prostate cancer samples into …