[HTML][HTML] PYY (3-36) and exendin-4 reduce food intake and activate neuronal circuits in a synergistic manner in mice
M Kjaergaard, CBG Salinas, JF Rehfeld, A Secher… - Neuropeptides, 2019 - Elsevier
Abstract Peptide YY (3-36)((PYY (3-36)) and glucagon like peptide 1 (GLP-1) in combination
reduce food intake and body weight in an additive or synergistic manner in animal models
and in humans. Nevertheless, the mechanisms behind are not completely understood. The
present study aims to investigate the effect of combining PYY (3-36) and the GLP-1 receptor
agonist exendin-4 (Ex4) by examining acute food intake and global neuronal activation as
measured by c-fos in C57BL/6 J mice. An additive reduction in food intake was found 1.5 h …
reduce food intake and body weight in an additive or synergistic manner in animal models
and in humans. Nevertheless, the mechanisms behind are not completely understood. The
present study aims to investigate the effect of combining PYY (3-36) and the GLP-1 receptor
agonist exendin-4 (Ex4) by examining acute food intake and global neuronal activation as
measured by c-fos in C57BL/6 J mice. An additive reduction in food intake was found 1.5 h …