[HTML][HTML] Intestinal glucagon-like peptide-1 effects on food intake: Physiological relevance and emerging mechanisms
JP Krieger - Peptides, 2020 - Elsevier
The gut-brain hormone glucagon-like peptide-1 (GLP-1) has received immense attention
over the last couple of decades for its widespread metabolic effects. Notably, intestinal GLP-
1 has been recognized as an endogenous satiation signal. Yet, the underlying mechanisms
and the pathophysiological relevance of intestinal GLP-1 in obesity remain unclear. This
review first recapitulates early findings indicating that intestinal GLP-1 is an endogenous
satiation signal, whose eating effects are primarily mediated by vagal afferents. Second, on …
over the last couple of decades for its widespread metabolic effects. Notably, intestinal GLP-
1 has been recognized as an endogenous satiation signal. Yet, the underlying mechanisms
and the pathophysiological relevance of intestinal GLP-1 in obesity remain unclear. This
review first recapitulates early findings indicating that intestinal GLP-1 is an endogenous
satiation signal, whose eating effects are primarily mediated by vagal afferents. Second, on …