Microbial colonization history modulates anxiety-like and complex social behavior in mice
I Kamimura, R Kaneko, H Morita, K Mogi… - Neuroscience …, 2021 - Elsevier
Microbiome composition has a pivotal role in neurobehavioral development. However, there
is limited information about the role of the microbiome in sociability of mice in complex social
contexts. Germ-free (GF) mice were reared in a microbiota-free environment until postnatal
day 21 and then transferred to a room containing specific pathogen free (SPF) mice. At 9
weeks old, group social behaviors were measured for three GF mice and three SPF mice
unfamiliar to each other. GF mice spent less time in the center area of the arena and there …
is limited information about the role of the microbiome in sociability of mice in complex social
contexts. Germ-free (GF) mice were reared in a microbiota-free environment until postnatal
day 21 and then transferred to a room containing specific pathogen free (SPF) mice. At 9
weeks old, group social behaviors were measured for three GF mice and three SPF mice
unfamiliar to each other. GF mice spent less time in the center area of the arena and there …