Novel developments in vagal afferent nutrient sensing and its role in energy homeostasis
G de Lartigue, C Diepenbroek - Current opinion in pharmacology, 2016 - Elsevier
Highlights•Vagal afferent neurons (VANs) directly sense fats, carbohydrates and possibly
proteins.•Update on GLP1 and ghrelin signaling in VANs.•Novel role of VANs in the long-
term control of food intake from genetic and bariatric surgery studies.•Clinical evidence that
targeting vagus nerve is a viable treatment of obesity.•Potential role of VANs in
thermogenesis, reward, and circadian rhythm.Vagal afferent neurons (VANs) play an
important role in the control of food intake by signaling nutrient type and quantity to the brain …
proteins.•Update on GLP1 and ghrelin signaling in VANs.•Novel role of VANs in the long-
term control of food intake from genetic and bariatric surgery studies.•Clinical evidence that
targeting vagus nerve is a viable treatment of obesity.•Potential role of VANs in
thermogenesis, reward, and circadian rhythm.Vagal afferent neurons (VANs) play an
important role in the control of food intake by signaling nutrient type and quantity to the brain …