[HTML][HTML] Increased colonic propionate reduces anticipatory reward responses in the human striatum to high-energy foods
CS Byrne, ES Chambers, H Alhabeeb, N Chhina… - The American journal of …, 2016 - Elsevier
Background: Short-chain fatty acids (SCFAs), metabolites produced through the microbial
fermentation of nondigestible dietary components, have key roles in energy homeostasis.
Animal research suggests that colon-derived SCFAs modulate feeding behavior via central
mechanisms. In humans, increased colonic production of the SCFA propionate acutely
reduces energy intake. However, evidence of an effect of colonic propionate on the human
brain or reward-based eating behavior is currently unavailable. Objectives: We investigated …
fermentation of nondigestible dietary components, have key roles in energy homeostasis.
Animal research suggests that colon-derived SCFAs modulate feeding behavior via central
mechanisms. In humans, increased colonic production of the SCFA propionate acutely
reduces energy intake. However, evidence of an effect of colonic propionate on the human
brain or reward-based eating behavior is currently unavailable. Objectives: We investigated …