IL-17 and Th17 cells in tuberculosis
E Torrado, AM Cooper - Cytokine & growth factor reviews, 2010 - Elsevier
Tuberculosis is primarily a disease of the lung. Constant expression of cellular immunity in
this organ is required to control Mycobacterium tuberculosis growth, but this can also result
in chronic inflammation and pathologic consequences. During primary tuberculosis both IFN-
γ and IL-17 are induced: both are potent inflammatory cytokines capable of inducing
expression of chemokines that promote cell recruitment and granuloma organization
throughout infection. During the chronic phase, a balance between Th1 and Th17 responses …
this organ is required to control Mycobacterium tuberculosis growth, but this can also result
in chronic inflammation and pathologic consequences. During primary tuberculosis both IFN-
γ and IL-17 are induced: both are potent inflammatory cytokines capable of inducing
expression of chemokines that promote cell recruitment and granuloma organization
throughout infection. During the chronic phase, a balance between Th1 and Th17 responses …