[HTML][HTML] Trigger-happy resident memory CD4+ T cells inhabit the human lungs
AE Oja, B Piet, C Helbig, R Stark, D Van Der Zwan… - Mucosal …, 2018 - Elsevier
Resident memory T cells (T RM) reside in the lung epithelium and mediate protective
immunity against respiratory pathogens. Although lung CD8+ T RM have been extensively
characterized, the properties of CD4+ T RM remain unclear. Here we determined the
transcriptional signature of CD4+ T RM, identified by the expression of CD103, retrieved
from human lung resection material. Various tissue homing molecules were specifically
upregulated on CD4+ T RM, whereas expression of tissue egress and lymph node homing …
immunity against respiratory pathogens. Although lung CD8+ T RM have been extensively
characterized, the properties of CD4+ T RM remain unclear. Here we determined the
transcriptional signature of CD4+ T RM, identified by the expression of CD103, retrieved
from human lung resection material. Various tissue homing molecules were specifically
upregulated on CD4+ T RM, whereas expression of tissue egress and lymph node homing …