Pulmonary Mycobacterium bovis BCG vaccination confers dose-dependent superior protection compared to that of subcutaneous vaccination
N Aguilo, AM Toledo, EM Lopez-Roman… - Clinical and Vaccine …, 2014 - Am Soc Microbiol
N Aguilo, AM Toledo, EM Lopez-Roman, E Perez-Herran, E Gormley, J Rullas-Trincado…
Clinical and Vaccine Immunology, 2014•Am Soc MicrobiolWorldwide, the Mycobacterium bovis BCG vaccine is one of the most widely used vaccines.
However, it appears to be ineffective in preventing pulmonary tuberculosis. Here, we show
that pulmonary BCG vaccination of mice with a broad dose range provides superior
protection against Mycobacterium tuberculosis challenge compared to that of subcutaneous
vaccination.
However, it appears to be ineffective in preventing pulmonary tuberculosis. Here, we show
that pulmonary BCG vaccination of mice with a broad dose range provides superior
protection against Mycobacterium tuberculosis challenge compared to that of subcutaneous
vaccination.
Abstract
Worldwide, the Mycobacterium bovis BCG vaccine is one of the most widely used vaccines. However, it appears to be ineffective in preventing pulmonary tuberculosis. Here, we show that pulmonary BCG vaccination of mice with a broad dose range provides superior protection against Mycobacterium tuberculosis challenge compared to that of subcutaneous vaccination.
American Society for Microbiology