[HTML][HTML] Metal-specific CD4+ T-cell responses induced by beryllium exposure in HLA-DP2 transgenic mice
MT Falta, AN Tinega, DG Mack, NA Bowerman… - Mucosal …, 2016 - Elsevier
Chronic beryllium disease (CBD) is a granulomatous lung disorder that is associated with
the accumulation of beryllium (Be)-specific CD4+ T cells into the lung. Genetic susceptibility
is linked to HLA-DPB1 alleles that possess a glutamic acid at position 69 (βGlu69), and HLA-
DPB1* 02: 01 is the most prevalent βGlu69-containing allele. Using HLA-DP2 transgenic
(Tg) mice, we developed a model of CBD that replicates the major features of the human
disease. Here we characterized the T-cell receptor (TCR) repertoire of Be-responsive CD4+ …
the accumulation of beryllium (Be)-specific CD4+ T cells into the lung. Genetic susceptibility
is linked to HLA-DPB1 alleles that possess a glutamic acid at position 69 (βGlu69), and HLA-
DPB1* 02: 01 is the most prevalent βGlu69-containing allele. Using HLA-DP2 transgenic
(Tg) mice, we developed a model of CBD that replicates the major features of the human
disease. Here we characterized the T-cell receptor (TCR) repertoire of Be-responsive CD4+ …